TAGMe DNA Methylation Kuzindikira kwa Pan-cancer
Zogulitsa
Chithandizo chochepa kwambiri:Chotsani osachepera 3mL magazi a venous kapena mitundu ina yoyenera yachipatala
Kulondola:Landirani data yayikulu ndi ma algorithm a AI, tsatanetsatane wa mayeso≥95%
Kusinthasintha:Kuzindikira kumodzi kumatha kuphimba zotupa 25 zowopsa kwambiri.
Gawo loyambirira:Kulowererapo pakuwunika koyambirira kwa khansa, panthawi yonse yowunikira komanso kuchiza chotupa.
Zabwino:Khalani ndi miyezo ya golide yozindikira methylation - ukadaulo wotsatizana wa pyrophosphate, mutha kumaliza mayeso mkati mwa maola anayi.
Ulamuliro:Ndi zovomerezeka za 54 zapadziko lonse lapansi komanso zapakhomo, zotsatira zofufuzira zoyenera zasindikizidwa mu Cancer Research, Genome Research ndi magazini ena otchuka padziko lonse lapansi.
Kuzindikira Mfundo
Kuzindikira khansa yonse ndi plasma ctDNA methylation test tests zomwe zimapangidwa ndi TAGMe, zomwe zimafunika osachepera 3ml yamagazi athunthu kuti agwire bwino ndikuzindikira malo a methylation a malo apadera a ctDNA, kuti akwaniritse kuwunika koyambirira komanso kuwunika kolondola. cha chotupacho.
Kachitidwe
Potsimikizira zitsanzo zachipatala zoposa 3000, mlingo wa methylation wa TAGMe m'matumbo a chotupa unali wapamwamba kwambiri kuposa wamtundu wamba.Chifukwa chake, TAGMe itha kugwiritsidwa ntchito ngati cholembera cha khansa ya pan-cancer pozindikira makhansa osiyanasiyana.
Majini okhudzana ndi histone ali ndi hypermethylated mu khansa ya m'mapapo ndipo hypermethylated HIST1H4F imatha kukhala ngati biomarker ya pan-cancer.
--- Kafukufuku wa Khansa, IF: 12.7
Monga cholembera cha khansa ya pan-cancer, TAGMe ili ndi kutsimikizika kwakukulu komanso chidwi pakutsimikizira zitsanzo zachipatala, zomwe zili ndi tanthauzo lofunikira pakuzindikiritsa zotupa.
TAGMe imakhudzidwa muzotupa zosiyanasiyana zotupa pomwe mawonekedwe ake ndi akulu kuposa 95%,
Zochitika zantchito
Mbiri ya banja la khansa:Odwala khansa mwa achibale apafupi kapena ogwirizana.
Matenda a virus komanso matenda osatha:Monga HPV, HBV ndi matenda ena tizilombo, matumbo polyps, aakulu atrophic gastritis ndi chiwindi matenda enaake, etc.
Kuwonetsedwa ndi chilengedwe cha carcinogenic kwa nthawi yayitali:Kuwonetsedwa ndi chilengedwe cha radiation kapena mankhwala owopsa kwa nthawi yayitali.
Chiyembekezo cha chotupa:monga magazi osadziwika bwino a ukazi, hematochezia, mkodzo, tinthu tating'onoting'ono ta m'mapapo, kutentha thupi mosadziwika bwino kapena kuwonda, etc.
Zizoloŵezi zoipa za moyo wautali: Kusuta fodya kwa nthawi yayitali kapena kusuta fodya, kumwa mowa mwauchidakwa, kudya kwambiri kapena kumwa mowa mwauchidakwa, kudya mchere wambiri, zoziziritsa kukhosi, nkhungu, zakudya zosuta komanso zokazinga, etc.
Samalani za thanzi lanu:makamaka kwa gulu lazaka zopitilira 40
